Harnessing Endogenous Mechanisms for Targeted Drug Delivery (Original PDF from Publisher)

The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.

This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.

• Provides comprehensive insights into endogenous strategies for targeted drug delivery
• Highlights innovative techniques like using cells as Trojan Horse-Cloaking Particles
• Explores the clinical and commercial translation of these strategies
• Offers practical solutions to contemporary challenges in the area
• Emphasizes the role of disease-specific stimuli and plasma proteins in drug delivery