Movement Disorders: Genetics and Models (ORIGINAL PDF from Publisher)

by Mark S. LeDoux (Editor)

This volume will cover the entire spectrum of movement disorders with a heavy focus on models driven by neurogenetics. The field of movement disorders has grown exponentially in the past decade and is now a multidisciplinary science involving neuroscience, genetics, pharmacology and animal model research. Marked advances have occurred in the genetics of movement disorders and this has driven the development of many new animal, computational and cellular models. The explosion of new genes and associated animal models is overwhelming. This book serves as the only single source available for accessing integrated and organized current information in the field. It is an essential reference for clinicians, clinician-scientists and bench scientists interested in the study of movement disorders.

The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to

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